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Research Article

DNA Damage–Induced Bcl-xL Deamidation Is Mediated by NHE-1 Antiport Regulated Intracellular pH

  • Rui Zhao,

    Affiliation: Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge, United Kingdom

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  • David Oxley,

    Affiliation: Protein Technologies Laboratory, The Babraham Institute, Babraham, Cambridge, United Kingdom

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  • Trevor S Smith,

    Affiliation: Protein Technologies Laboratory, The Babraham Institute, Babraham, Cambridge, United Kingdom

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  • George A Follows,

    Affiliation: Department of Haematology, University of Cambridge, Hills Road, Cambridge, United Kingdom

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  • Anthony R Green,

    Affiliation: Department of Haematology, University of Cambridge, Hills Road, Cambridge, United Kingdom

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  • Denis R Alexander mail

    To whom correspondence should be addressed. E-mail: denis.alexander@bbsrc.ac.uk

    Affiliation: Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge, United Kingdom

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  • Published: December 19, 2006
  • DOI: 10.1371/journal.pbio.0050001

About the Authors

Rui Zhao, Denis R Alexander
Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge, United Kingdom
David Oxley, Trevor S Smith
Protein Technologies Laboratory, The Babraham Institute, Babraham, Cambridge, United Kingdom
George A Follows, Anthony R Green
Department of Haematology, University of Cambridge, Hills Road, Cambridge, United Kingdom

Corresponding Author

Email: denis.alexander@bbsrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

RZ and DRA conceived and designed the experiments. RZ, DO, and TSS performed the experiments. RZ, DO, and TSS analyzed the data. GAF and ARG contributed reagents/materials/analysis tools. DRA wrote the paper.