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Research Article

Rescue of Progeria in Trichothiodystrophy by Homozygous Lethal Xpd Alleles

  • Jaan-Olle Andressoo,

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, Netherlands

    ¤a Current address: Institute of Biotechnology, University of Helsinki, Helsinki, Finland

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  • Judith Jans,

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, Netherlands

    ¤b Current address: Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America

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  • Jan de Wit,

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, Netherlands

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  • Frederic Coin,

    Affiliation: Institut de Genetique et de Biologie et Cellulaire, Strasbourg, France

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  • Deborah Hoogstraten,

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, Netherlands

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  • Marieke van de Ven,

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, Netherlands

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  • Wendy Toussaint,

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, Netherlands

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  • Jan Huijmans,

    Affiliation: Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, Netherlands

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  • H. Bing Thio,

    Affiliation: Department of Dermatology, Erasmus Medical Center, Rotterdam, Netherlands

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  • Wibeke J van Leeuwen,

    Affiliation: Department of Experimental Radiology, Erasmus Medical Center, Rotterdam, Netherlands

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  • Jan de Boer,

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, Netherlands

    ¤c Current address: Institute for Biomedical Technology, University of Twente, Bilthoven, Netherlands

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  • Jean-Marc Egly,

    Affiliation: Institut de Genetique et de Biologie et Cellulaire, Strasbourg, France

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  • Jan H. J Hoeijmakers,

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, Netherlands

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  • Gijsbertus T. J van der Horst,

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, Netherlands

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  • James R Mitchell mail

    To whom correspondence should be addressed. E-mail: j.mitchell@erasmusmc.nl

    Affiliation: Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, Netherlands

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  • Published: October 03, 2006
  • DOI: 10.1371/journal.pbio.0040322

About the Authors

Jaan-Olle Andressoo, Judith Jans, Jan de Wit, Deborah Hoogstraten, Marieke van de Ven, Wendy Toussaint, Jan de Boer, Jan H. J Hoeijmakers, Gijsbertus T. J van der Horst, James R Mitchell
Medical Genetics Center, Department of Cell Biology and Genetics, Center of Biomedical Genetics, Erasmus Medical Center, Rotterdam, Netherlands
Frederic Coin, Jean-Marc Egly
Institut de Genetique et de Biologie et Cellulaire, Strasbourg, France
Jan Huijmans
Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, Netherlands
H. Bing Thio
Department of Dermatology, Erasmus Medical Center, Rotterdam, Netherlands
Wibeke J van Leeuwen
Department of Experimental Radiology, Erasmus Medical Center, Rotterdam, Netherlands

Corresponding Author

Email: j.mitchell@erasmusmc.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JOA, JJ, JHJH, GTJvdH, and JRM conceived and designed the experiments. JOA, JJ, JdW, FC, DH, MvdV, WT, JH, WJvL, and JRM performed the experiments. JOA, JJ, JdW, FC, DH, MvdV, JH, HBT, WJvL, JME, JHJH, and JRM analyzed the data. JdB and GTJvdH contributed reagents/materials/analysis tools. JOA, JHJH, and JRM wrote the paper.