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Research Article

Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch

  • Jun Lu,

    Affiliations: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Mischa Machius,

    Affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Irina Dulubova,

    Affiliations: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Han Dai,

    Affiliations: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Thomas C Südhof,

    Affiliations: Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Diana R Tomchick,

    Affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Josep Rizo mail

    To whom correspondence should be addressed. E-mail: jose@arnie.swmed.edu

    Affiliations: Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Published: June 06, 2006
  • DOI: 10.1371/journal.pbio.0040192

About the Authors

Jun Lu, Mischa Machius, Irina Dulubova, Han Dai, Diana R Tomchick, Josep Rizo
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Jun Lu, Irina Dulubova, Han Dai, Josep Rizo
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Thomas C Südhof
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Thomas C Südhof
Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Thomas C Südhof
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Corresponding Author

Email: jose@arnie.swmed.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

JL, MM, ID, HD, TCS, DRT, and JR conceived and designed the experiments. JL, MM, ID, HD, and DRT performed the experiments. JL, MM, ID, HD, DRT, and JR analyzed the data. JL contributed reagents/materials/analysis tools. JR wrote the paper.