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Research Article

Fgf9 and Wnt4 Act as Antagonistic Signals to Regulate Mammalian Sex Determination

  • Yuna Kim,

    Affiliation: Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Akio Kobayashi,

    Affiliation: Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Ryohei Sekido,

    Affiliation: Division of Developmental Genetics, MRC National Institute for Medical Research, London, United Kingdom

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  • Leo DiNapoli,

    Affiliation: Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Jennifer Brennan,

    Affiliation: Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Marie-Christine Chaboissier,

    Affiliation: INSERM U470, Centre de Biochimie, Parc Valrose, Nice, France

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  • Francis Poulat,

    Affiliation: Institut de Génétique Humaine, CNRS UPR1142, Montpellier, France

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  • Richard R Behringer,

    Affiliation: Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Robin Lovell-Badge,

    Affiliation: Division of Developmental Genetics, MRC National Institute for Medical Research, London, United Kingdom

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  • Blanche Capel mail

    To whom correspondence should be addressed. E-mail: b.capel@cellbio.duke.edu

    Affiliation: Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America

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  • Published: May 23, 2006
  • DOI: 10.1371/journal.pbio.0040187

About the Authors

Yuna Kim, Leo DiNapoli, Jennifer Brennan, Blanche Capel
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America
Akio Kobayashi, Richard R Behringer
Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
Ryohei Sekido, Robin Lovell-Badge
Division of Developmental Genetics, MRC National Institute for Medical Research, London, United Kingdom
Marie-Christine Chaboissier
INSERM U470, Centre de Biochimie, Parc Valrose, Nice, France
Francis Poulat
Institut de Génétique Humaine, CNRS UPR1142, Montpellier, France

Corresponding Author

Email: b.capel@cellbio.duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

YK, AK, and BC conceived and designed the experiments. YK, AK, LD, and JB performed the experiments. YK, RLB, and BC analyzed the data. YK, RS, MCC, FP, RRB, RLB, and BC contributed reagents/materials/analysis tools. YK and BC wrote the paper with significant input from RLB.