Advertisement
Research Article

Crystal Structure of the HSV-1 Fc Receptor Bound to Fc Reveals a Mechanism for Antibody Bipolar Bridging

  • Elizabeth R Sprague,

    Affiliation: Division of Biology, California Institute of Technology, Pasadena, California, United States of America

    X
  • Chu Wang,

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

    X
  • David Baker,

    Affiliations: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

    X
  • Pamela J Bjorkman mail

    To whom correspondence should be addressed. E-mail: bjorkman@caltech.edu

    Affiliations: Division of Biology, California Institute of Technology, Pasadena, California, United States of America, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California United States of America

    X
  • Published: May 02, 2006
  • DOI: 10.1371/journal.pbio.0040148

About the Authors

Elizabeth R Sprague, Pamela J Bjorkman
Division of Biology, California Institute of Technology, Pasadena, California, United States of America
Chu Wang, David Baker
Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
David Baker
Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America
Pamela J Bjorkman
Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California United States of America

Corresponding Author

Email: bjorkman@caltech.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ERS and PJB conceived and designed the experiments. ERS and CW performed the experiments. CW and DB contributed reagents/materials/analysis tools. ERS, CW, DB, and PJB analyzed the data and wrote the paper.