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Research Article

Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context

  • Amanda J Mikels,

    Affiliations: Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Roel Nusse mail

    To whom correspondence should be addressed. E-mail: rnusse@stanford.edu

    Affiliations: Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: April 04, 2006
  • DOI: 10.1371/journal.pbio.0040115

About the Authors

Amanda J Mikels, Roel Nusse
Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, United States of America
Amanda J Mikels, Roel Nusse
Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

Corresponding Author

Email: rnusse@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

AJM and RN conceived and designed the experiments. AJM performed the experiments. AJM and RN analyzed the data. AJM and RN contributed reagents/materials/analysis tools. AJM and RN wrote the paper.