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Research Article

Ancient and Recent Positive Selection Transformed Opioid cis-Regulation in Humans

  • Matthew V Rockman mail,

    To whom correspondence should be addressed. E-mail: mrockman@princeton.edu

    Affiliation: Department of Biology, Duke University, Durham, North Carolina, United States of America

    ¤a Current address: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

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  • Matthew W Hahn,

    Affiliations: Department of Biology, Duke University, Durham, North Carolina, United States of America, Center for Population Biology, University of California, Davis, California, United States of America

    ¤b Current address: Department of Biology and School of Informatics, Indiana University, Bloomington, Indiana, United States of America

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  • Nicole Soranzo,

    Affiliation: Department of Biology, University College, London, United Kingdom

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  • Fritz Zimprich,

    Affiliation: Department of Clinical Neurology, Medical University of Vienna, Vienna, Austria

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  • David B Goldstein,

    Affiliations: Department of Biology, Duke University, Durham, North Carolina, United States of America, Department of Biology, University College, London, United Kingdom, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Gregory A Wray

    Affiliations: Department of Biology, Duke University, Durham, North Carolina, United States of America, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Published: November 15, 2005
  • DOI: 10.1371/journal.pbio.0030387

About the Authors

Matthew V Rockman, Matthew W Hahn, David B Goldstein, Gregory A Wray
Department of Biology, Duke University, Durham, North Carolina, United States of America
Matthew W Hahn
Center for Population Biology, University of California, Davis, California, United States of America
Nicole Soranzo, David B Goldstein
Department of Biology, University College, London, United Kingdom
Fritz Zimprich
Department of Clinical Neurology, Medical University of Vienna, Vienna, Austria
David B Goldstein, Gregory A Wray
Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

Corresponding Author

Email: mrockman@princeton.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MVR, MWH, NS, FZ, DBG, and GAW conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, and wrote the paper.