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Research Article

The Case for Selection at CCR5-Δ32

  • Pardis C Sabeti mail,

    To whom correspondence should be addressed. E-mail: pardis@broad.mit.edu

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Emily Walsh,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Steve F Schaffner,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Patrick Varilly,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Ben Fry,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Holli B Hutcheson,

    Affiliation: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, United States of America

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  • Mike Cullen,

    Affiliation: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, United States of America

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  • Tarjei S Mikkelsen,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Jessica Roy,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Nick Patterson,

    Affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

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  • Richard Cooper,

    Affiliation: Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois, United States of America

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  • David Reich,

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Departments of Genetics and Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

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  • David Altshuler,

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Departments of Genetics and Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Molecular Biology and Center for Human Genetic Research, Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Stephen O'Brien,

    Affiliation: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, United States of America

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  • Eric S Lander

    Affiliations: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: November 01, 2005
  • DOI: 10.1371/journal.pbio.0030378

About the Authors

Pardis C Sabeti, Emily Walsh, Steve F Schaffner, Patrick Varilly, Ben Fry, Tarjei S Mikkelsen, Jessica Roy, Nick Patterson, David Reich, David Altshuler, Eric S Lander
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America
Pardis C Sabeti
Harvard Medical School, Boston, Massachusetts, United States of America
Holli B Hutcheson, Mike Cullen, Stephen O'Brien
Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, United States of America
Richard Cooper
Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois, United States of America
David Reich, David Altshuler
Departments of Genetics and Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
David Altshuler
Department of Molecular Biology and Center for Human Genetic Research, Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Eric S Lander
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Eric S Lander
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
Eric S Lander
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: pardis@broad.mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

PCS, EW, MC, DA, SO, and ESL conceived and designed the experiments. PCS, EW, MC, and JR performed the experiments. PCS, SFS, PV, BF, TSM, NP, and DR analyzed the data. SFS, PV, BF, RC, HH, and ESL contributed reagents/materials/analysis tools. PCS, EW, DA, and ESL wrote the paper.