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Research Article

Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses

  • Grégoire Altan-Bonnet,

    Affiliation: Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ronald N Germain mail

    To whom correspondence should be addressed. E-mail: rgermain@niaid.nih.gov

    Affiliation: Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: October 25, 2005
  • DOI: 10.1371/journal.pbio.0030356

About the Authors

Grégoire Altan-Bonnet, Ronald N Germain
Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: rgermain@niaid.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

GAB and RNG conceived and designed the experiments. GAB performed the experiments. GAB and RNG analyzed the data and wrote the paper.