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Research Article

Facilitation of Task Performance and Removal of the Effects of Sleep Deprivation by an Ampakine (CX717) in Nonhuman Primates

  • Linda J Porrino,

    Affiliation: Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

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  • James B Daunais,

    Affiliation: Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

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  • Gary A Rogers,

    Affiliation: Cortex Pharmaceuticals, Irvine, California, United States of America

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  • Robert E Hampson,

    Affiliation: Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

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  • Sam A Deadwyler mail

    To whom correspondence should be addressed. E-mail: sdeadwyl@wfubmc.edu

    Affiliation: Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America

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  • Published: August 23, 2005
  • DOI: 10.1371/journal.pbio.0030299

About the Authors

Linda J Porrino, James B Daunais, Robert E Hampson, Sam A Deadwyler
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, United States of America
Gary A Rogers
Cortex Pharmaceuticals, Irvine, California, United States of America

Corresponding Author

Email: sdeadwyl@wfubmc.edu

Competing Interests

Portions of the research were supported by Cortex Pharmaceuticals in that Cortex donated the drug CX717, and GAR, an employee of Cortex, contributed expertise in drug formulation, experimental design, and manuscript review. This collaboration provided access to certain technologies and scientific expertise for basic research in the study of the effects of sleep deprivation on cognitive performance.

Author Contributions

LJP, JBD, GAR, REH, and SAD conceived and designed the experiments. LJP, JBD, REH, and SAD performed the experiments. LJP, JBD, GAR, REH, and SAD analyzed the data. GAR contributed reagents/materials/analysis tools. LJP, JBD, GAR, REH, and SAD wrote the paper.