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Research Article

Functional Identification of Catalytic Metal Ion Binding Sites within RNA

  • James L Hougland,

    Affiliation: Department of Chemistry, University of Chicago, Illinois, United States of America

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  • Alexander V Kravchuk,

    Affiliation: Department of Biochemistry, Stanford University, California, United States of America

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  • Daniel Herschlag mail,

    To whom correspondence should be addressed. E-mail: herschla@cmgm.stanford.edu (DH), Email: jpicciri@uchicago.edu (JP)

    Affiliation: Department of Biochemistry, Stanford University, California, United States of America

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  • Joseph A Piccirilli mail

    To whom correspondence should be addressed. E-mail: herschla@cmgm.stanford.edu (DH), Email: jpicciri@uchicago.edu (JP)

    Affiliations: Department of Chemistry, University of Chicago, Illinois, United States of America, Department of Biochemistry and Molecular Biology, University of Chicago, Illinois, United States of America, Howard Hughes Medical Institute, University of Chicago, Illinois, United States of America

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  • Published: August 16, 2005
  • DOI: 10.1371/journal.pbio.0030277

About the Authors

James L Hougland, Joseph A Piccirilli
Department of Chemistry, University of Chicago, Illinois, United States of America
Alexander V Kravchuk, Daniel Herschlag
Department of Biochemistry, Stanford University, California, United States of America
Joseph A Piccirilli
Department of Biochemistry and Molecular Biology, University of Chicago, Illinois, United States of America
Joseph A Piccirilli
Howard Hughes Medical Institute, University of Chicago, Illinois, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

JLH, AVK, DH, and JAP conceived and designed the experiments. JLH performed the experiments and analyzed the data. JLH and AVK contributed reagents/materials/analysis tools. JLH, DH, and JAP wrote the paper.