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Research Article

Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein

  • Klaus Förstemann,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Yukihide Tomari,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Tingting Du,

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Vasily V Vagin,

    Affiliation: Institute of Molecular Genetics of RAS, Moscow, Russia

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  • Ahmet M Denli,

    Affiliation: Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

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  • Diana P Bratu,

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Carla Klattenhoff,

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • William E Theurkauf,

    Affiliation: Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Phillip D Zamore mail

    To whom correspondence should be addressed. E-mail: phillip.zamore@umassmed.edu

    Affiliation: Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Published: May 24, 2005
  • DOI: 10.1371/journal.pbio.0030236

About the Authors

Klaus Förstemann, Yukihide Tomari, Tingting Du, Phillip D Zamore
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Vasily V Vagin
Institute of Molecular Genetics of RAS, Moscow, Russia
Ahmet M Denli
Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
Diana P Bratu, Carla Klattenhoff, William E Theurkauf
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Corresponding Author

Email: phillip.zamore@umassmed.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

KF, YT, TD, VVV, WET, and PDZ conceived and designed the experiments. KF, YT, TD, VVV, DPB, CK, and WET performed the experiments. KF, YT, TD, VVV, DPB, CK, WET, and PDZ analyzed the data. KF, YT, TD, VVV, AMD, DPB, CK, WET, and PDZ contributed reagents/materials/analysis tools. KF, WET, YT, and PDZ wrote the paper.