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Research Article

Engineering a Dimeric Caspase-9: A Re-evaluation of the Induced Proximity Model for Caspase Activation

  • Yang Chao equal contributor,

    equal contributor Contributed equally to this work with: Yang Chao, Eric N Shiozaki

    Affiliation: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey, United States of America

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  • Eric N Shiozaki equal contributor,

    equal contributor Contributed equally to this work with: Yang Chao, Eric N Shiozaki

    Affiliation: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey, United States of America

    X
  • Srinivasa M Srinivasula,

    Affiliation: Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Daniel J Rigotti,

    Affiliation: Department of Biology, Haverford College, Haverford, Pennsylvania, United States of America

    X
  • Robert Fairman,

    Affiliation: Department of Biology, Haverford College, Haverford, Pennsylvania, United States of America

    X
  • Yigong Shi mail

    To whom correspondence should be addressed. E-mail: yshi@molbio.princeton.edu

    Affiliation: Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey, United States of America

    X
  • Published: May 10, 2005
  • DOI: 10.1371/journal.pbio.0030183

About the Authors

Yang Chao, Eric N Shiozaki, Yigong Shi
Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey, United States of America
Srinivasa M Srinivasula
Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Daniel J Rigotti, Robert Fairman
Department of Biology, Haverford College, Haverford, Pennsylvania, United States of America

Corresponding Author

Email: yshi@molbio.princeton.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

YC, ENS, and YS conceived and designed the experiments. YC, ENS, SMS, DJR, and RF performed the experiments. SMS, DJR, and RF analyzed the data. YC, ENS, SMS, RF, and YS discussed the results. YC, ENS, and YS wrote the paper.