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Research Article

Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance

  • Ryan T Cirz,

    Affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America

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  • Jodie K Chin,

    Affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America

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  • David R Andes,

    Affiliation: The Department of Medicine, Section of Infectious Disease, University of Wisconsin Medical School, Madison, Wisconsin, United States of America

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  • Valérie de Crécy-Lagard,

    Affiliation: Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • William A Craig,

    Affiliation: The Department of Medicine, Section of Infectious Disease, University of Wisconsin Medical School, Madison, Wisconsin, United States of America

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  • Floyd E Romesberg mail

    To whom correspondence should be addressed. E-mail: floyd@scripps.edu

    Affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America

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  • Published: May 10, 2005
  • DOI: 10.1371/journal.pbio.0030176

About the Authors

Ryan T Cirz, Jodie K Chin, Floyd E Romesberg
Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States of America
David R Andes, William A Craig
The Department of Medicine, Section of Infectious Disease, University of Wisconsin Medical School, Madison, Wisconsin, United States of America
Valérie de Crécy-Lagard
Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America

Corresponding Author

Email: floyd@scripps.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

RTC, JKC, and FER conceived and designed the experiments. RTC, DRA, and WAC performed the experiments. RTC, JKC, DRA, WAC, and FER analyzed the data. VdCL contributed reagents/materials/analysis tools. RTC, JKC, and FER wrote the paper.