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Research Article

Oxygenation Inhibits the Physiological Tissue-Protecting Mechanism and Thereby Exacerbates Acute Inflammatory Lung Injury

  • Manfred Thiel,

    Affiliations: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Clinic of Anaesthesiology, University of Munich, Germany

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  • Alexander Chouker,

    Affiliations: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Clinic of Anaesthesiology, University of Munich, Germany

    X
  • Akio Ohta,

    Affiliations: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, New England Inflammation and Tissue Protection Institute, Northeastern University, Boston, Massachusetts, United States of America

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  • Edward Jackson,

    Affiliation: Pharmacology/Medicine Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania, United States of America

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  • Charles Caldwell,

    Affiliation: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Patrick Smith,

    Affiliation: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Dmitry Lukashev,

    Affiliations: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, New England Inflammation and Tissue Protection Institute, Northeastern University, Boston, Massachusetts, United States of America

    X
  • Iris Bittmann,

    Affiliation: Pathology, Klinikum Grosshadern, University of Munich, Germany

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  • Michail V Sitkovsky mail

    To whom correspondence should be addressed. E-mail: m.sitkovsky@neu.edu

    Affiliations: Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, New England Inflammation and Tissue Protection Institute, Northeastern University, Boston, Massachusetts, United States of America

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  • Published: May 03, 2005
  • DOI: 10.1371/journal.pbio.0030174

About the Authors

Manfred Thiel, Alexander Chouker, Akio Ohta, Charles Caldwell, Patrick Smith, Dmitry Lukashev, Michail V Sitkovsky
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Manfred Thiel, Alexander Chouker
Clinic of Anaesthesiology, University of Munich, Germany
Akio Ohta, Dmitry Lukashev, Michail V Sitkovsky
New England Inflammation and Tissue Protection Institute, Northeastern University, Boston, Massachusetts, United States of America
Edward Jackson
Pharmacology/Medicine Pittsburgh, University of Pittsburgh School of Medicine, Pennsylvania, United States of America
Iris Bittmann
Pathology, Klinikum Grosshadern, University of Munich, Germany

Corresponding Author

Email: m.sitkovsky@neu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MT and MVS conceived and designed the experiments. MT, AC, AO, EJ, CC, and PS performed the experiments. DL and IB analyzed the data. MT and MVS wrote the paper.