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Research Article

A Scan for Positively Selected Genes in the Genomes of Humans and Chimpanzees

  • Rasmus Nielsen mail,

    To whom correspondence should be addressed. E-mail: rasmus@binf.ku.dk

    Affiliations: Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America, Center for Bioinformatics, University of Copenhagen, Denmark

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  • Carlos Bustamante,

    Affiliation: Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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  • Andrew G Clark,

    Affiliation: Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

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  • Stephen Glanowski,

    Affiliation: Applied Biosystems, Rockville, Maryland, United States of America

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  • Timothy B Sackton,

    Affiliation: Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America

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  • Melissa J Hubisz,

    Affiliation: Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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  • Adi Fledel-Alon,

    Affiliation: Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America

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  • David M Tanenbaum,

    Affiliation: Celera Genomics, Rockville, Maryland, United States of America

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  • Daniel Civello,

    Affiliation: Celera Diagnostics, Alameda, California, United States of America

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  • Thomas J White,

    Affiliation: Celera Diagnostics, Alameda, California, United States of America

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  • John J. Sninsky,

    Affiliation: Celera Diagnostics, Alameda, California, United States of America

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  • Mark D Adams,

    Affiliation: Celera Genomics, Rockville, Maryland, United States of America

    ¤ Current address: Department of Genetics, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Michele Cargill

    Affiliation: Celera Diagnostics, Alameda, California, United States of America

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  • Published: May 03, 2005
  • DOI: 10.1371/journal.pbio.0030170

About the Authors

Rasmus Nielsen, Carlos Bustamante, Melissa J Hubisz, Adi Fledel-Alon
Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America
Rasmus Nielsen
Center for Bioinformatics, University of Copenhagen, Denmark
Andrew G Clark, Timothy B Sackton
Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
Stephen Glanowski
Applied Biosystems, Rockville, Maryland, United States of America
David M Tanenbaum, Mark D Adams
Celera Genomics, Rockville, Maryland, United States of America
Daniel Civello, Thomas J White, John J. Sninsky, Michele Cargill
Celera Diagnostics, Alameda, California, United States of America

Corresponding Author

Email: rasmus@binf.ku.dk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

SG, DMT, DC, TJW, JJS, MDA, and MC conceived and designed the experiments and performed the experiments. RN, CB, AGC, TBS, MJH, and AFA analyzed the data and contributed reagents/materials/analysis tools. RN, CB, AGC, MDA, and MC wrote the paper.