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Research Article

An Unbiased Cell Morphology–Based Screen for New, Biologically Active Small Molecules

  • Masahiro Tanaka,

    Affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

    X
  • Raynard Bateman,

    Affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

    X
  • Daniel Rauh,

    Affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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  • Eugeni Vaisberg,

    Affiliation: Cytokinetics Inc., South San Francisco, California, United States of America

    X
  • Shyam Ramachandani,

    Affiliation: Cytokinetics Inc., South San Francisco, California, United States of America

    X
  • Chao Zhang,

    Affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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  • Kirk C Hansen,

    Affiliation: Department of Pharmaceutical Chemistry, Mass Spectrometry Facility, University of California, San Francisco, California, United States of America

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  • Alma L Burlingame,

    Affiliation: Department of Pharmaceutical Chemistry, Mass Spectrometry Facility, University of California, San Francisco, California, United States of America

    X
  • Jay K Trautman,

    Affiliation: Cytokinetics Inc., South San Francisco, California, United States of America

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  • Kevan M Shokat mail,

    To whom correspondence should be addressed. E-mail: shokat@cmp.ucsf.edu

    Affiliation: Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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  • Cynthia L Adams

    Affiliation: Cytokinetics Inc., South San Francisco, California, United States of America

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  • Published: April 05, 2005
  • DOI: 10.1371/journal.pbio.0030128

About the Authors

Masahiro Tanaka, Raynard Bateman, Daniel Rauh, Chao Zhang, Kevan M Shokat
Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America
Eugeni Vaisberg, Shyam Ramachandani, Jay K Trautman, Cynthia L Adams
Cytokinetics Inc., South San Francisco, California, United States of America
Kirk C Hansen, Alma L Burlingame
Department of Pharmaceutical Chemistry, Mass Spectrometry Facility, University of California, San Francisco, California, United States of America

Corresponding Author

Email: shokat@cmp.ucsf.edu

Competing Interests

EV, SR, JKT, and CLA are affiliated with/employed by Cytokinetics.

Author Contributions

MT, RB, DR, CLA, and KS conceived and designed the experiments. MT, RB, DR, SR, KCH, and CLA performed the experiments. MT, RB, DR, EV, and CLA analyzed the data. CZ, ALB, and JKT contributed reagents/materials/analysis tools. KS wrote the paper.