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Research Article

PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

  • Teresa C Leone,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • John J Lehman,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Brian N Finck,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Paul J Schaeffer,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Adam R Wende,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

    X
  • Sihem Boudina,

    Affiliation: Program in Human Molecular Biology and Genetics, Division of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, Utah, United States of America

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  • Michael Courtois,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • David F Wozniak,

    Affiliation: Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Nandakumar Sambandam,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Carlos Bernal-Mizrachi,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Zhouji Chen,

    Affiliation: Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • John O. Holloszy,

    Affiliation: Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Denis M Medeiros,

    Affiliation: Department of Human Nutrition, Kansas State University, Manhattan, Kansas, United States of America

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  • Robert E Schmidt,

    Affiliation: Department of Pathology, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Jeffrey E Saffitz,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Pathology, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • E. Dale Abel,

    Affiliation: Program in Human Molecular Biology and Genetics, Division of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, Utah, United States of America

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  • Clay F Semenkovich,

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Daniel P Kelly mail

    To whom correspondence should be addressed. E-mail: dkelly@im.wustl.edu

    Affiliations: Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, United States of America

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  • Published: March 15, 2005
  • DOI: 10.1371/journal.pbio.0030101

About the Authors

Teresa C Leone, John J Lehman, Brian N Finck, Paul J Schaeffer, Adam R Wende, Michael Courtois, Nandakumar Sambandam, Carlos Bernal-Mizrachi, Jeffrey E Saffitz, Clay F Semenkovich, Daniel P Kelly
Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri, United States of America
Teresa C Leone, John J Lehman, Brian N Finck, Paul J Schaeffer, Adam R Wende, Michael Courtois, Nandakumar Sambandam, Carlos Bernal-Mizrachi, Zhouji Chen, John O. Holloszy, Clay F Semenkovich, Daniel P Kelly
Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
Sihem Boudina, E. Dale Abel
Program in Human Molecular Biology and Genetics, Division of Endocrinology, Metabolism and Diabetes, University of Utah, Salt Lake City, Utah, United States of America
David F Wozniak
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
Denis M Medeiros
Department of Human Nutrition, Kansas State University, Manhattan, Kansas, United States of America
Robert E Schmidt, Jeffrey E Saffitz
Department of Pathology, Washington University School of Medicine, St Louis, Missouri, United States of America
Daniel P Kelly
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri, United States of America
Daniel P Kelly
Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, United States of America

Corresponding Author

Email: dkelly@im.wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

TCL, JJL, BNF, PJS, and DPK conceived and designed the experiments. TCL, JJL, BNF, PJS, ARW, SB, MC, DFW, NS, CBM, ZC, DMM, RES, and EDA performed the experiments. TCL, JJL, BNF, PJS, ARW, SB, MC, DFW, NS, CBM, ZC, JOH, DMM, RES, JES, EDA, CFS, and DPK analyzed the data. TCL, BNF, and DPK wrote the paper.