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Research Article

Highly Conserved Non-Coding Sequences Are Associated with Vertebrate Development

  • Adam Woolfe,

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Martin Goodson,

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Debbie K Goode,

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Phil Snell,

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Gayle K McEwen,

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Tanya Vavouri,

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Sarah F Smith,

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Phil North,

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Heather Callaway,

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Krys Kelly,

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Klaudia Walter,

    Affiliation: Medical Research Council Biostatistics Unit, Institute of Public Health, Addenbrookes Hospital, Cambridge, United Kingdom

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  • Irina Abnizova,

    Affiliation: Medical Research Council Biostatistics Unit, Institute of Public Health, Addenbrookes Hospital, Cambridge, United Kingdom

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  • Walter Gilks,

    Affiliation: Medical Research Council Biostatistics Unit, Institute of Public Health, Addenbrookes Hospital, Cambridge, United Kingdom

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  • Yvonne J. K Edwards,

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Julie E Cooke,

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Greg Elgar mail

    To whom correspondence should be addressed. E-mail: gelgar@rfcgr.mrc.ac.uk

    Affiliation: Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom

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  • Published: November 11, 2004
  • DOI: 10.1371/journal.pbio.0030007

About the Authors

Adam Woolfe, Martin Goodson, Debbie K Goode, Phil Snell, Gayle K McEwen, Tanya Vavouri, Sarah F Smith, Phil North, Heather Callaway, Krys Kelly, Yvonne J. K Edwards, Julie E Cooke, Greg Elgar
Medical Research Council Rosalind Franklin Centre for Genomics Research, Hinxton, Cambridge, United Kingdom
Klaudia Walter, Irina Abnizova, Walter Gilks
Medical Research Council Biostatistics Unit, Institute of Public Health, Addenbrookes Hospital, Cambridge, United Kingdom

Corresponding Author

Email: gelgar@rfcgr.mrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

MG and GE designed the study. AW, MG, DKG, PS, SFS, PN, and JEC performed the experiments. AW, MG, DKG, PS, GKM, TV, KK, JEC, and GE analysed the data. GKM, TV, HC, KW, IA, WG, and YJKE contributed reagents/materials/analysis tools. AW, GKM, JEC, and GE wrote the paper.