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Research Article

Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages

  • Christiane E Wobus,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Stephanie M Karst,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Larissa B Thackray,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Kyeong-Ok Chang,

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Stanislav V Sosnovtsev,

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Gaël Belliot,

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Anne Krug,

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

    ¤Current address: Department of Medicine, Technical University Munich, Germany

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  • Jason M Mackenzie,

    Affiliation: Sir Albert Sakzewski Virus Research Centre, Royal Children's Hospital, and Clinical Medical Virology Centre, University of Queensland, Brisbane, Australia

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  • Kim Y Green,

    Affiliation: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

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  • Herbert W. Virgin IV mail

    To whom correspondence should be addressed. E-mail: virgin@wustl.edu

    Affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Published: November 30, 2004
  • DOI: 10.1371/journal.pbio.0020432

About the Authors

Christiane E Wobus, Stephanie M Karst, Larissa B Thackray, Anne Krug, Herbert W. Virgin IV
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Kyeong-Ok Chang, Stanislav V Sosnovtsev, Gaël Belliot, Kim Y Green
Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America
Jason M Mackenzie
Sir Albert Sakzewski Virus Research Centre, Royal Children's Hospital, and Clinical Medical Virology Centre, University of Queensland, Brisbane, Australia

Corresponding Author

Email: virgin@wustl.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

CEW, SMK, LBT, JMM, KYG, and HWV conceived and designed the experiments. CEW, SMK, LBT, KOC, SSS, GB, JMM, and KYG performed the experiments. CEW, SMK, LBT, KOC, SSS, GB, AK, JMM, KYG, HWV analyzed the data. AK contributed reagents/materials/analysis tools. CEW, KYG, and HWV wrote the paper.