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Research Article

Distinct Genomic Integration of MLV and SIV Vectors in Primate Hematopoietic Stem and Progenitor Cells

  • Peiman Hematti equal contributor,

    equal contributor Contributed equally to this work with: Peiman Hematti, Bum-Kee Hong, Cole Ferguson

    Affiliation: Hematology Branch, National Institutes of Health, Bethesda, Maryland, United States of America

    ¤1 Current address: Department of Medicine, Hematology/Bone Marrow Transplant Section, University of Wisconsin-Madison Medical School, Madison, Wisconsin, United States of America

    X
  • Bum-Kee Hong equal contributor,

    equal contributor Contributed equally to this work with: Peiman Hematti, Bum-Kee Hong, Cole Ferguson

    Affiliation: Hematology Branch, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Cole Ferguson equal contributor,

    equal contributor Contributed equally to this work with: Peiman Hematti, Bum-Kee Hong, Cole Ferguson

    Affiliation: Hematology Branch, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Rima Adler,

    Affiliation: Hematology Branch, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Hideki Hanawa,

    Affiliation: Experimental Hematology Division, Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Stephanie Sellers,

    Affiliation: Hematology Branch, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Ingeborg E Holt,

    Affiliation: Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Craig E Eckfeldt,

    Affiliation: Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, United States of America

    X
  • Yugal Sharma,

    Affiliation: Bioinformatics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Manfred Schmidt,

    Affiliation: Department of Internal Medicine, University of Freiburg, , Freiburg, Germany

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  • Christof von Kalle,

    Affiliation: Division of Experimental Hematology, Children's Hospital Research Foundation, Cincinnati, Ohio, United States of America

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  • Derek A Persons,

    Affiliation: Experimental Hematology Division, Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Eric M Billings,

    Affiliation: Bioinformatics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Catherine M Verfaillie,

    Affiliation: Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, United States of America

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  • Arthur W Nienhuis,

    Affiliation: Experimental Hematology Division, Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Tyra G Wolfsberg,

    Affiliation: Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Cynthia E Dunbar mail,

    To whom correspondence should be addressed. E-mail: dunbarc@nhlbi.nih.gov

    Affiliation: Hematology Branch, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Boris Calmels

    Affiliation: Hematology Branch, National Institutes of Health, Bethesda, Maryland, United States of America

    ¤2 Current address: Centre de Thérapie Cellulaire, Institut Paoli-Calmettes, Marseille, France

    X
  • Published: November 23, 2004
  • DOI: 10.1371/journal.pbio.0020423

About the Authors

Peiman Hematti, Bum-Kee Hong, Cole Ferguson, Rima Adler, Stephanie Sellers, Cynthia E Dunbar, Boris Calmels
Hematology Branch, National Institutes of Health, Bethesda, Maryland, United States of America
Hideki Hanawa, Derek A Persons, Arthur W Nienhuis
Experimental Hematology Division, Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Ingeborg E Holt, Tyra G Wolfsberg
Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Craig E Eckfeldt, Catherine M Verfaillie
Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, United States of America
Yugal Sharma, Eric M Billings
Bioinformatics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Manfred Schmidt
Department of Internal Medicine, University of Freiburg, , Freiburg, Germany
Christof von Kalle
Division of Experimental Hematology, Children's Hospital Research Foundation, Cincinnati, Ohio, United States of America

Corresponding Author

Email: dunbarc@nhlbi.nih.gov

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

TGW, CED, and BC conceived and designed the experiments. PH, BKH, CF, RA, SS, and BC performed the experiments. TGW, CED, and BC analyzed the data. HH, IEH, CEE, YS, MS, CvK, DAP, EMB, CMV, AWN, and TGW contributed reagents/materials/analysis tools. TGW, CED, and BC wrote the paper.