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Research Article

Adaptive Amplification and Point Mutation Are Independent Mechanisms: Evidence for Various Stress-Inducible Mutation Mechanisms

  • P. J Hastings mail,

    To whom correspondence should be addressed. E-mail: hastings@bcm.tmc.edu

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Andrew Slack,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Joseph F Petrosino,

    Affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Susan M Rosenberg

    Affiliations: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Biochemistry and Molecular Biology and Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America

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  • Published: November 23, 2004
  • DOI: 10.1371/journal.pbio.0020399

About the Authors

P. J Hastings, Andrew Slack, Joseph F Petrosino, Susan M Rosenberg
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America
Susan M Rosenberg
Department of Biochemistry and Molecular Biology and Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America

Corresponding Author

Email: hastings@bcm.tmc.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

PH and SMR conceived and designed the experiments. PH, AS, and JFP performed the experiments. PH, AS, and JFP analyzed the data. SMR contributed reagents/materials/analysis tools. PH and SMR wrote the paper.