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Research Article

Parallel Chemical Genetic and Genome-Wide RNAi Screens Identify Cytokinesis Inhibitors and Targets

  • Ulrike S Eggert mail,

    To whom correspondence should be addressed. E-mail: ulrike_eggert@hms.harvard.edu

    Affiliations: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Amy A Kiger,

    Affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Constance Richter,

    Affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Zachary E Perlman,

    Affiliations: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Norbert Perrimon,

    Affiliations: Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Timothy J Mitchison,

    Affiliations: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Christine M Field

    Affiliation: Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: October 05, 2004
  • DOI: 10.1371/journal.pbio.0020379

About the Authors

Ulrike S Eggert, Constance Richter, Zachary E Perlman, Timothy J Mitchison, Christine M Field
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America
Ulrike S Eggert, Zachary E Perlman, Timothy J Mitchison
Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America
Amy A Kiger, Norbert Perrimon
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Norbert Perrimon
Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: ulrike_eggert@hms.harvard.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

USE, AAK, NP, TJM, and CMF conceived and designed the experiments. USE, AAK, and CR performed the experiments. USE, AAK, and CR analyzed the data. USE, AAK, CR, ZEP, and CMF contributed reagents/materials/ analysis tools. USE, AAK, TJM, and CMF wrote the paper.