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Research Article

BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis

  • R. Daniel Rudic equal contributor,

    equal contributor Contributed equally to this work with: R. Daniel Rudic, Peter McNamara

    Affiliation: Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Peter McNamara equal contributor,

    equal contributor Contributed equally to this work with: R. Daniel Rudic, Peter McNamara

    Affiliation: Phenomix Corporation, La Jolla, California, United States of America

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  • Anne-Maria Curtis,

    Affiliation: Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Raymond C Boston,

    Affiliation: School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania, United States of America

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  • Satchidananda Panda,

    Affiliation: The Genomics Institute of the Novartis Research Foundation, La Jolla, California, United States of America

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  • John B Hogenesch,

    Affiliation: The Genomics Institute of the Novartis Research Foundation, La Jolla, California, United States of America

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  • Garret A FitzGerald mail

    To whom correspondence should be addressed. E-mail: garret@spirit.gcrc.upenn.edu

    Affiliation: Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: November 02, 2004
  • DOI: 10.1371/journal.pbio.0020377

About the Authors

R. Daniel Rudic, Anne-Maria Curtis, Garret A FitzGerald
Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Peter McNamara
Phenomix Corporation, La Jolla, California, United States of America
Raymond C Boston
School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania, United States of America
Satchidananda Panda, John B Hogenesch
The Genomics Institute of the Novartis Research Foundation, La Jolla, California, United States of America

Corresponding Author

Email: garret@spirit.gcrc.upenn.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

RDR, PM, and GAF conceived and designed the experiments. RDR, PM, AMC, and SP performed the experiments. RDR, RB, and JH analyzed the data. RB and JH contributed reagents/materials/analysis tools. RDR wrote the paper.