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Research Article

Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

  • Matt Kaeberlein,

    Affiliation: Departments of Genome Sciences and Medicine, University of Washington, Seattle, Washington, United States of America

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  • Kathryn T Kirkland,

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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  • Stanley Fields,

    Affiliations: Departments of Genome Sciences and Medicine, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

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  • Brian K Kennedy mail

    To whom correspondence should be addressed. E-mail: bkenn@u.washington.edu

    Affiliation: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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  • Published: August 24, 2004
  • DOI: 10.1371/journal.pbio.0020296

About the Authors

Matt Kaeberlein, Stanley Fields
Departments of Genome Sciences and Medicine, University of Washington, Seattle, Washington, United States of America
Kathryn T Kirkland, Brian K Kennedy
Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
Stanley Fields
Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

Corresponding Author

Email: bkenn@u.washington.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

MK, KTK, SF, and BKK conceived and designed the experiments. MK, KTK, and BKK performed the experiments and analyzed the data. MK, KTK, SF, and BKK contributed reagents/materials/analysis tools. MK and BKK wrote the paper.