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Research Article

A Drosophila Pattern Recognition Receptor Contains a Peptidoglycan Docking Groove and Unusual L,D-Carboxypeptidase Activity

  • Chung-I Chang,

    Affiliation: Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Sébastien Pili-Floury,

    Affiliation: Centre de Génétique Moléculaire du Centre National de la Recherche Scientifique, Gif-sur-Yvette, France

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  • Mireille Hervé,

    Affiliation: Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Paris-Sud, Orsay, France

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  • Claudine Parquet,

    Affiliation: Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Paris-Sud, Orsay, France

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  • Yogarany Chelliah,

    Affiliation: Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Bruno Lemaitre,

    Affiliation: Centre de Génétique Moléculaire du Centre National de la Recherche Scientifique, Gif-sur-Yvette, France

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  • Dominique Mengin-Lecreulx mail,

    To whom correspondence should be addressed. E-mail: dominique.mengin-lecreulx@ebp.u-psud.fr (DM), Email: Johann.Deisenhofer@UTSouthwestern.edu (JD)

    Affiliation: Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Paris-Sud, Orsay, France

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  • Johann Deisenhofer mail

    To whom correspondence should be addressed. E-mail: dominique.mengin-lecreulx@ebp.u-psud.fr (DM), Email: Johann.Deisenhofer@UTSouthwestern.edu (JD)

    Affiliation: Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Published: September 07, 2004
  • DOI: 10.1371/journal.pbio.0020277

About the Authors

Chung-I Chang, Yogarany Chelliah, Johann Deisenhofer
Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Sébastien Pili-Floury, Bruno Lemaitre
Centre de Génétique Moléculaire du Centre National de la Recherche Scientifique, Gif-sur-Yvette, France
Mireille Hervé, Claudine Parquet, Dominique Mengin-Lecreulx
Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Université de Paris-Sud, Orsay, France

Corresponding Authors

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

CIC, BL, and DML conceived and designed the experiments. CIC, SPF, BL, and DML performed the experiments. CIC, SPF, BL, DML, and JD analyzed the data. MH, CP, and YC contributed reagents/materials/analysis tools. CIC, BL, DML, and JD wrote the paper.