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Research Article

Single Nucleotide Polymorphism–Based Validation of Exonic Splicing Enhancers

  • William G Fairbrother,

    Affiliations: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Dirk Holste,

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Christopher B Burge mail,

    To whom correspondence should be addressed. E-mail: cburge@mit.edu (CB), Email: sharppa@mit.edu (PS)

    Affiliation: Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Phillip A Sharp mail

    To whom correspondence should be addressed. E-mail: cburge@mit.edu (CB), Email: sharppa@mit.edu (PS)

    Affiliations: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, McGovern Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: August 31, 2004
  • DOI: 10.1371/journal.pbio.0020268

About the Authors

William G Fairbrother, Phillip A Sharp
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
William G Fairbrother, Dirk Holste, Christopher B Burge, Phillip A Sharp
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Phillip A Sharp
McGovern Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

WGF conceived and designed the experiments. WGF performed the experiments. WGF analyzed the data. WGF and DH contributed reagents/materials/analysis tools. CBB and PAS were the principal investigators. WGF wrote the paper.