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Research Article

The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

  • Jan Karlseder,

    Affiliation: Laboratory for Cell Biology and Genetics, Rockefeller University, New York, United States of America

    ¤Current address: Regulatory Biology, The Salk Institute for Biological Studies, La Jolla, California, United States of America

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  • Kristina Hoke,

    Affiliation: Laboratory for Cell Biology and Genetics, Rockefeller University, New York, United States of America

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  • Olga K Mirzoeva,

    Affiliation: Memorial Sloan–Kettering Cancer Center, New York, New York, United States of America

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  • Christopher Bakkenist,

    Affiliation: Department of Hematology and Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • Michael B Kastan,

    Affiliation: Department of Hematology and Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

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  • John H. J Petrini,

    Affiliation: Memorial Sloan–Kettering Cancer Center, New York, New York, United States of America

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  • Titia de Lange mail

    To whom correspondence should be addressed. E-mail: delange@mail.rockefeller. edu

    Affiliation: Laboratory for Cell Biology and Genetics, Rockefeller University, New York, United States of America

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  • Published: August 17, 2004
  • DOI: 10.1371/journal.pbio.0020240

About the Authors

Jan Karlseder, Kristina Hoke, Titia de Lange
Laboratory for Cell Biology and Genetics, Rockefeller University, New York, United States of America
Christopher Bakkenist, Michael B Kastan
Department of Hematology and Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Olga K Mirzoeva, John H. J Petrini
Memorial Sloan–Kettering Cancer Center, New York, New York, United States of America

Corresponding Author

Email: delange@mail.rockefeller. edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

JK, KMH, and TdL conceived and designed the experiments. JK, KMH, and OM performed the experiments. JK, KMH, JHJP, and TdL analyzed the data. JK, KMH, CB, MBK, JHJP, and TdL contributed reagents/materials/analysis tools. JK, KMH, JHJP, and TdL wrote the paper.