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Research Article

The Zebrafish moonshine Gene Encodes Transcriptional Intermediary Factor 1γ, an Essential Regulator of Hematopoiesis

  • David G Ransom,

    Affiliation: Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

    ¤Current address: Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon, United States of America

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  • Nathan Bahary,

    Affiliation: Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Knut Niss,

    Affiliation: Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • David Traver,

    Affiliation: Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Caroline Burns,

    Affiliation: Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Nikolaus S Trede,

    Affiliation: Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Noelle Paffett-Lugassy,

    Affiliation: Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Walter J Saganic,

    Affiliation: Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • C. Anthoney Lim,

    Affiliation: Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Candace Hersey,

    Affiliation: Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Yi Zhou,

    Affiliation: Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Bruce A Barut,

    Affiliations: Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America, Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Shuo Lin,

    Affiliation: Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California, United States of America

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  • Paul D Kingsley,

    Affiliation: Department of Pediatrics and Center for Human Genetics and Molecular Pediatric Disease, University of Rochester Medical Center, Rochester, New York, United States of America

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  • James Palis,

    Affiliation: Department of Pediatrics and Center for Human Genetics and Molecular Pediatric Disease, University of Rochester Medical Center, Rochester, New York, United States of America

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  • Stuart H Orkin,

    Affiliations: Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America, Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Leonard I Zon

    Affiliations: Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America, Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: August 17, 2004
  • DOI: 10.1371/journal.pbio.0020237

About the Authors

Bruce A Barut, Stuart H Orkin, Leonard I Zon
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America
David G Ransom, Nathan Bahary, Knut Niss, David Traver, Caroline Burns, Nikolaus S Trede, Noelle Paffett-Lugassy, Walter J Saganic, C. Anthoney Lim, Candace Hersey, Yi Zhou, Bruce A Barut, Stuart H Orkin, Leonard I Zon
Division of Hematology/Oncology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Shuo Lin
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California, United States of America
Paul D Kingsley, James Palis
Department of Pediatrics and Center for Human Genetics and Molecular Pediatric Disease, University of Rochester Medical Center, Rochester, New York, United States of America

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

DGR, NB, KN, DT, CB, NST, YZ, JP, SHO, and LIZ conceived and designed the experiments. DGR, NB, KN, DT, CB, NST, NPL, WJS, CAL, CH, BAB, and PDK performed the experiments. DGR, NB, KN, DT, CB, NST, NPL, YZ, JP, SHO, and LIZ analyzed the data. DGR, NB, KN, DT, NST, YZ, BAB, SL, and JP contributed reagents/materials/analysis tools. DGR, NB, KN, DT, and LIZ wrote the paper.