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Research Article

Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution

  • Andrew Fortna equal contributor,

    equal contributor Contributed equally to this work with: Andrew Fortna, Young Kim

    Affiliation: Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

    X
  • Young Kim equal contributor,

    equal contributor Contributed equally to this work with: Andrew Fortna, Young Kim

    Affiliation: Department of Pathology, Stanford University, Stanford, California, United States of America

    X
  • Erik MacLaren,

    Affiliation: Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

    X
  • Kriste Marshall,

    Affiliation: Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

    X
  • Gretchen Hahn,

    Affiliation: Colorado Genetics Laboratory, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

    X
  • Lynne Meltesen,

    Affiliation: Colorado Genetics Laboratory, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

    X
  • Matthew Brenton,

    Affiliation: Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

    X
  • Raquel Hink,

    Affiliation: Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

    X
  • Sonya Burgers,

    Affiliation: Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

    X
  • Tina Hernandez-Boussard,

    Affiliation: Department of Genetics, Stanford University, Stanford, California, United States of America

    X
  • Anis Karimpour-Fard,

    Affiliation: Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

    X
  • Deborah Glueck,

    Affiliation: Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

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  • Loris McGavran,

    Affiliation: Colorado Genetics Laboratory, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

    X
  • Rebecca Berry,

    Affiliation: Colorado Genetics Laboratory, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

    X
  • Jonathan Pollack mail,

    To whom correspondence should be addressed. E-mail: pollack1@stanford.edu (JP), Email: james.sikela@uchsc.edu (JS)

    Affiliation: Department of Pathology, Stanford University, Stanford, California, United States of America

    X
  • James M Sikela mail

    To whom correspondence should be addressed. E-mail: pollack1@stanford.edu (JP), Email: james.sikela@uchsc.edu (JS)

    Affiliation: Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

    X
  • Published: July 13, 2004
  • DOI: 10.1371/journal.pbio.0020207

About the Authors

Andrew Fortna, Erik MacLaren, Kriste Marshall, Matthew Brenton, Raquel Hink, Sonya Burgers, James M Sikela
Department of Pharmacology and Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, United States of America
Young Kim, Jonathan Pollack
Department of Pathology, Stanford University, Stanford, California, United States of America
Gretchen Hahn, Lynne Meltesen, Loris McGavran, Rebecca Berry
Colorado Genetics Laboratory, University of Colorado Health Sciences Center, Denver, Colorado, United States of America
Tina Hernandez-Boussard
Department of Genetics, Stanford University, Stanford, California, United States of America
Anis Karimpour-Fard, Deborah Glueck
Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, Colorado, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

JP and JS conceived and designed the experiments. AF, YK, EM, and GH performed the experiments. AF, EM, KM, LM, MB, SB, AK-F, DG, LM, RB, JP, and JS analyzed the data. AF, YK, EM, RH, TH-B, and JP contributed reagents/materials/analysis tools. JS wrote the paper.