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Research Article

α-Actinin-4-Mediated FSGS: An Inherited Kidney Disease Caused by an Aggregated and Rapidly Degraded Cytoskeletal Protein

  • June Yao,

    Affiliation: Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Tu Cam Le,

    Affiliation: Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Claudine H Kos,

    Affiliation: Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Joel M Henderson,

    Affiliation: Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Phillip G Allen,

    Affiliation: Hematology Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Bradley M Denker,

    Affiliation: Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Martin R Pollak mail

    To whom correspondence should be addressed. E-mail: mpollak@rics.bwh.harvard.edu

    Affiliation: Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: June 15, 2004
  • DOI: 10.1371/journal.pbio.0020167

About the Authors

June Yao, Tu Cam Le, Claudine H Kos, Bradley M Denker, Martin R Pollak
Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Joel M Henderson
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
Phillip G Allen
Hematology Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: mpollak@rics.bwh.harvard.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

JY, PGA, BMD, and MRP conceived and designed the experiments. JY, TCL, CHK, JMH, and PGA performed the experiments. JY, JMH, PGA, BMD, and MRP analyzed the data. JH, PGA, and MRP contributed reagents/materials/analysis tools. JY and MRP wrote the paper.