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Research Article

Noise Minimization in Eukaryotic Gene Expression

  • Hunter B Fraser mail,

    To whom correspondence should be addressed. E-mail: hunter@ocf.berkeley.edu

    Affiliation: Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America

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  • Aaron E Hirsh,

    Affiliation: Department of Biological Sciences, Stanford University, Stanford, California, United States of America

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  • Guri Giaever,

    Affiliation: Stanford Genome Technology Center, Stanford, California, United States of America

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  • Jochen Kumm,

    Affiliation: Stanford Genome Technology Center, Stanford, California, United States of America

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  • Michael B Eisen

    Affiliations: Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America, Genome Sciences Department, Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

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  • Published: April 27, 2004
  • DOI: 10.1371/journal.pbio.0020137

About the Authors

Hunter B Fraser, Michael B Eisen
Department of Molecular and Cell Biology, University of California, Berkeley, California, United States of America
Aaron E Hirsh
Department of Biological Sciences, Stanford University, Stanford, California, United States of America
Guri Giaever, Jochen Kumm
Stanford Genome Technology Center, Stanford, California, United States of America
Michael B Eisen
Genome Sciences Department, Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Corresponding Author

Email: hunter@ocf.berkeley.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

HBF conceived and performed the analyses. HBF and AEH wrote the paper. GG and JK contributed fitness data. MBE edited the paper and provided a nurturing environment.