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Research Article

Early Myocardial Function Affects Endocardial Cushion Development in Zebrafish

  • Thomas Bartman,

    Affiliations: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America, Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Divisions of Neonatology, Pulmonary Biology, and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America

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  • Emily C Walsh,

    Affiliations: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Kuo-Kuang Wen,

    Affiliation: Department of Biochemistry, University of Iowa College of Medicine, Iowa City, Iowa, United States of America

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  • Melissa McKane,

    Affiliation: Department of Biochemistry, University of Iowa College of Medicine, Iowa City, Iowa, United States of America

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  • Jihui Ren,

    Affiliation: Department of Biochemistry, University of Iowa College of Medicine, Iowa City, Iowa, United States of America

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  • Jonathan Alexander,

    Affiliations: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America, Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, United States of America

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  • Peter A Rubenstein,

    Affiliation: Department of Biochemistry, University of Iowa College of Medicine, Iowa City, Iowa, United States of America

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  • Didier Y. R Stainier mail

    To whom correspondence should be addressed. E-mail: didier_stainier@biochem.ucsf.edu

    Affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

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  • Published: May 11, 2004
  • DOI: 10.1371/journal.pbio.0020129

About the Authors

Thomas Bartman, Emily C Walsh, Jonathan Alexander, Didier Y. R Stainier
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America
Thomas Bartman
Department of Pediatrics, University of California, San Francisco, San Francisco, California, United States of America
Thomas Bartman
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
Thomas Bartman
Divisions of Neonatology, Pulmonary Biology, and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America
Emily C Walsh
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
Kuo-Kuang Wen, Melissa McKane, Jihui Ren, Peter A Rubenstein
Department of Biochemistry, University of Iowa College of Medicine, Iowa City, Iowa, United States of America
Jonathan Alexander
Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: didier_stainier@biochem.ucsf.edu

Author Contributions

TB, PAR, and DYRS conceived and designed the experiments. TB, K-KW, MM, and JR performed the experiments. TB, ECW, JA, PAR, and DYRS analyzed the data. ECW and JA contributed reagents/materials/analysis tools. TB, PAR, and DYRS wrote the paper.