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Research Article

pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia

  • Karl Simin,

    Affiliation: Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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  • Hua Wu,

    Affiliation: Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    ¤Current address: Phenomix Corporation, La Jolla, California, United States of America

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  • Lucy Lu,

    Affiliation: Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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  • Dan Pinkel,

    Affiliation: Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, United States of America

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  • Donna Albertson,

    Affiliation: Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, United States of America

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  • Robert D Cardiff,

    Affiliation: Center for Comparative Medicine, University of California, Davis, Davis, California, United States of America

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  • Terry Van Dyke mail

    To whom correspondence should be addressed. E-mail: tvdlab@med.unc.edu

    Affiliation: Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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  • Published: February 17, 2004
  • DOI: 10.1371/journal.pbio.0020022

About the Authors

Karl Simin, Hua Wu, Lucy Lu, Terry Van Dyke
Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
Dan Pinkel, Donna Albertson
Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, United States of America
Robert D Cardiff
Center for Comparative Medicine, University of California, Davis, Davis, California, United States of America

Corresponding Author

Email: tvdlab@med.unc.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

KS, HW, and TVD conceived and designed the experiments. KS, HW, and LL performed the experiments. KS, HW, RDC, and TVD analyzed the data. DP and DA contributed reagents/materials/analysis tools. KS and TVD wrote the paper.