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Research Article

Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

  • Howard Y Chang,

    Affiliations: Department of Dermatology, Stanford University School of Medicine, Stanford, California, United States of America, Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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  • Julie B Sneddon,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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  • Ash A Alizadeh,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

    ¤1 Current address: Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California, United States of America

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  • Ruchira Sood,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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  • Rob B West,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Kelli Montgomery,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Jen-Tsan Chi,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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  • Matt van de Rijn,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • David Botstein,

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

    ¤2 Current address: Lewis–Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

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  • Patrick O Brown mail

    To whom correspondence should be addressed. E-mail: pbrown@pmgm2.stanford.edu

    Affiliations: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: January 13, 2004
  • DOI: 10.1371/journal.pbio.0020007

About the Authors

Howard Y Chang
Department of Dermatology, Stanford University School of Medicine, Stanford, California, United States of America
Howard Y Chang, Julie B Sneddon, Ash A Alizadeh, Ruchira Sood, Jen-Tsan Chi, Patrick O Brown
Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America
Rob B West, Kelli Montgomery, Matt van de Rijn
Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
David Botstein
Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
Patrick O Brown
Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

Corresponding Author

Email: pbrown@pmgm2.stanford.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

HYC, DB, and POB conceived and designed the experiments. HYC, JBS, RS, and KM performed the experiments. HYC, JBS, AAA, RBW, JTC, MVDR, DB, and POB analyzed the data. HYC and POB wrote the paper.