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Research Article

T Cell Receptor-Independent Basal Signaling via Erk and Abl Kinases Suppresses RAG Gene Expression

  • Jeroen P Roose,

    Affiliations: Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America, Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America

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  • Maximilian Diehn,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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  • Michael G Tomlinson,

    Affiliations: Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America, Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America

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  • Joseph Lin,

    Affiliations: Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America, Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America

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  • Ash A Alizadeh,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

    ¤1Present address: Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America

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  • David Botstein,

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

    ¤2Present address: Lewis-Sigler Institute, Princeton University, Princeton, New Jersey, United States of America

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  • Patrick O Brown,

    Affiliations: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Arthur Weiss mail

    To whom correspondence should be addressed. E-mail: aweiss@medicine.ucsf.edu

    Affiliations: Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America, Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, United States of America, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, San Francisco, California, United States of America

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  • Published: November 17, 2003
  • DOI: 10.1371/journal.pbio.0000053

About the Authors

Jeroen P Roose, Michael G Tomlinson, Joseph Lin, Arthur Weiss
Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America
Jeroen P Roose, Michael G Tomlinson, Joseph Lin, Arthur Weiss
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America
Maximilian Diehn, Ash A Alizadeh, Patrick O Brown
Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America
David Botstein
Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America
Patrick O Brown
Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America
Arthur Weiss
Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, California, United States of America
Arthur Weiss
Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: aweiss@medicine.ucsf.edu

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

JPR and AW conceived and designed the experiments. JPR, MD, MGT, JL, and AAA performed the experiments. JPR, MD, MGT, and AAA analyzed the data. MD, JL, DB, and POB contributed reagents/materials/analysis tools. JPR wrote the paper. POB assisted in preparing the manuscript. AW guided JPR's project and assisted in writing the manuscript.