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Research Article

The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics

  • Lincoln D Stein mail,

    To whom correspondence should be addressed. E-mail: lstein@cshl.org

    Affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

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  • Zhirong Bao,

    Affiliations: Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

    X
  • Darin Blasiar,

    Affiliation: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Thomas Blumenthal,

    Affiliation: Biochemistry and Molecular Genetics, University of Colorado, Denver, Colorado, United States of America

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  • Michael R Brent,

    Affiliation: Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America

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  • Nansheng Chen,

    Affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

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  • Asif Chinwalla,

    Affiliation: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Laura Clarke,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Chris Clee,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Avril Coghlan,

    Affiliation: Department of Genetics, Trinity College, Dublin, Ireland

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  • Alan Coulson,

    Affiliations: Wellcome Trust Sanger Institute, Hinxton, United Kingdom, Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Peter D'Eustachio,

    Affiliations: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America, New York University School of Medicine, New York, New York, United States of America

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  • David H. A Fitch,

    Affiliation: Department of Biology, New York University, New York, New York, United States of America

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  • Lucinda A Fulton,

    Affiliation: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Robert E Fulton,

    Affiliation: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Sam Griffiths-Jones,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Todd W Harris,

    Affiliation: Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America

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  • LaDeana W Hillier,

    Affiliations: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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  • Ravi Kamath,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Patricia E Kuwabara,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Elaine R Mardis,

    Affiliation: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Marco A Marra,

    Affiliations: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America, Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada

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  • Tracie L Miner,

    Affiliation: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Patrick Minx,

    Affiliation: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • James C Mullikin,

    Affiliations: Wellcome Trust Sanger Institute, Hinxton, United Kingdom, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Robert W Plumb,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Jane Rogers,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Jacqueline E Schein,

    Affiliations: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America, Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada

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  • Marc Sohrmann,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • John Spieth,

    Affiliation: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Jason E Stajich,

    Affiliation: Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America

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  • Chaochun Wei,

    Affiliation: Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America

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  • David Willey,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Richard K Wilson,

    Affiliation: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Richard Durbin,

    Affiliation: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Robert H Waterston

    Affiliations: Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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  • Published: November 17, 2003
  • DOI: 10.1371/journal.pbio.0000045

About the Authors

Lincoln D Stein, Nansheng Chen, Peter D'Eustachio, Todd W Harris
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
Zhirong Bao
Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America
Darin Blasiar, Asif Chinwalla, Lucinda A Fulton, Robert E Fulton, LaDeana W Hillier, Elaine R Mardis, Marco A Marra, Tracie L Miner, Patrick Minx, Jacqueline E Schein, John Spieth, Richard K Wilson, Robert H Waterston
Genome Sequencing Center, Washington University School of Medicine, St. Louis, Missouri, United States of America
Thomas Blumenthal
Biochemistry and Molecular Genetics, University of Colorado, Denver, Colorado, United States of America
Michael R Brent, Chaochun Wei
Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, United States of America
Laura Clarke, Chris Clee, Alan Coulson, Sam Griffiths-Jones, Ravi Kamath, Patricia E Kuwabara, James C Mullikin, Robert W Plumb, Jane Rogers, Marc Sohrmann, David Willey, Richard Durbin
Wellcome Trust Sanger Institute, Hinxton, United Kingdom
Avril Coghlan
Department of Genetics, Trinity College, Dublin, Ireland
Peter D'Eustachio
New York University School of Medicine, New York, New York, United States of America
Zhirong Bao, LaDeana W Hillier, Robert H Waterston
Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America
Marco A Marra, Jacqueline E Schein
Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, Canada
James C Mullikin
National Institutes of Health, Bethesda, Maryland, United States of America
Jason E Stajich
Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America
Alan Coulson
Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
David H. A Fitch
Department of Biology, New York University, New York, New York, United States of America

Corresponding Author

Email: lstein@cshl.org

Competing Interests

The authors have declared that no conflicts of interest exist.

Author Contributions

L. W. Hillier, E. R. Mardis, J. C. Mullikin, J. Rogers, R. Durbin, and R. H. Waterston conceived and designed the experiments.