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Research Article

Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell Function as Well as Insulin Action

  • Inês Barroso mail,

    To whom correspondence should be addressed. E-mail: ib1@sanger.ac.uk (IB), Email: njw1004@medschl.cam.ac.uk (NW), Email: aschafer@ntlworld.com (AS), Email: sorahill@hgmp.mrc.ac.uk (SO)

    Affiliation: Incyte, Palo Alto, California, United States of America

    ¤ Current address: The Wellcome Trust Sanger Institute, Cambridge, United Kingdom.

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  • Jian'an Luan,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge Institute of Public Health, Cambridge, United Kingdom

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  • Rita P. S Middelberg,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge Institute of Public Health, Cambridge, United Kingdom

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  • Anne-Helen Harding,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge Institute of Public Health, Cambridge, United Kingdom

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  • Paul W Franks,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge Institute of Public Health, Cambridge, United Kingdom

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  • Rupert W Jakes,

    Affiliation: Department of Public Health and Primary Care, University of Cambridge Institute of Public Health, Cambridge, United Kingdom

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  • David Clayton,

    Affiliation: Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Cambridge, United Kingdom

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  • Alan J Schafer mail,

    To whom correspondence should be addressed. E-mail: ib1@sanger.ac.uk (IB), Email: njw1004@medschl.cam.ac.uk (NW), Email: aschafer@ntlworld.com (AS), Email: sorahill@hgmp.mrc.ac.uk (SO)

    Affiliation: Incyte, Palo Alto, California, United States of America

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  • Stephen O'Rahilly mail,

    To whom correspondence should be addressed. E-mail: ib1@sanger.ac.uk (IB), Email: njw1004@medschl.cam.ac.uk (NW), Email: aschafer@ntlworld.com (AS), Email: sorahill@hgmp.mrc.ac.uk (SO)

    Affiliation: Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

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  • Nicholas J Wareham mail

    To whom correspondence should be addressed. E-mail: ib1@sanger.ac.uk (IB), Email: njw1004@medschl.cam.ac.uk (NW), Email: aschafer@ntlworld.com (AS), Email: sorahill@hgmp.mrc.ac.uk (SO)

    Affiliation: Department of Public Health and Primary Care, University of Cambridge Institute of Public Health, Cambridge, United Kingdom

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  • Published: October 13, 2003
  • DOI: 10.1371/journal.pbio.0000020

About the Authors

Inês Barroso, Alan J Schafer
Incyte, Palo Alto, California, United States of America
Jian'an Luan, Rita P. S Middelberg, Anne-Helen Harding, Paul W Franks, Rupert W Jakes, Nicholas J Wareham
Department of Public Health and Primary Care, University of Cambridge Institute of Public Health, Cambridge, United Kingdom
David Clayton
Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Cambridge, United Kingdom
Stephen O'Rahilly
Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom

Corresponding Authors

Competing Interests

Portions of the research were supported by Incyte Corporation (formerly Incyte Genomics). This collaboration provided access to certain technologies and scientific expertise for basic research in the genetics of diabetes in return for possible shared intellectual property. The work described here is not subject to any patent filings or intellectual property protection and restrictions from free use of the information. IB and AJS were employees of Incyte at the time the research took place.

Author Contributions

IB, AJS, SO, and NW conceived and designed the experiments. IB, AJS, and NW performed the experiments or the fieldwork in the studies contributing data. IB, JL, RPSM, A-HH, PWF, RWJ, and NW analysed the data. DC contributed analysis tools and advice. All authors wrote the paper.