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Research Article

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation

  • Kazuhiko Higashida equal contributor,

    equal contributor Contributed equally to this work with: Kazuhiko Higashida, Sang Hyun Kim

    Affiliation: Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

    X
  • Sang Hyun Kim equal contributor,

    equal contributor Contributed equally to this work with: Kazuhiko Higashida, Sang Hyun Kim

    Affiliation: Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

    X
  • Su Ryun Jung,

    Affiliation: Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

    X
  • Meiko Asaka,

    Affiliation: Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

    X
  • John O. Holloszy mail,

    jhollosz@dom.wustl.edu

    Affiliation: Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

    X
  • Dong-Ho Han

    Affiliation: Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

    X
  • Published: July 09, 2013
  • DOI: 10.1371/journal.pbio.1001603

Reader Comments (3)

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Correction does not address all issues raised

Posted by PaulBrookes on 07 Feb 2014 at 20:34 GMT

The correction is a good start, but is deficient on several levels. I have outlined these in detail at a blog post on my lab' website (http://www.psblab.org/?p=...), but here's the short version...

1) The splicing issue raised WRT Figure 4A has not been addressed at all.
2) The phrase "inadvertently used the wrong blots" is inadequate, since in some cases it was not re-use of blots that was problematic, it was apparent re-use of single bands within blots. How exactly does one use the wrong band in a blot?
3) The correction images provided are askew - they appear to have been scanned in from paper copies and misaligned slightly during this process. There could be any number of reasons why files were not provided in a more direct manner (i.e. straight from the software they were generated in, without inserting a print-scan step). Regardless, the provision of apparent paper scans does nothing to enhance my confidence in these data.
4) The correction contains zero explanation for why it took 7 months to achieve.

No competing interests declared.