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Research Article

A Genome-Scale DNA Repair RNAi Screen Identifies SPG48 as a Novel Gene Associated with Hereditary Spastic Paraplegia

  • Mikołaj Słabicki,

    Affiliation: Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany

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  • Mirko Theis,

    Affiliation: Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany

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  • Dragomir B. Krastev,

    Affiliation: Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany

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  • Sergey Samsonov,

    Affiliation: Structural Bioinformatics, BIOTEC TU, Dresden, Germany

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  • Emeline Mundwiller,

    Affiliations: INSERM, Unit 975 Paris, France, Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Paris, France, CNRS, Unité Mixte de Recherche 7225 Paris, France

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  • Magno Junqueira,

    Affiliation: Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany

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  • Maciej Paszkowski-Rogacz,

    Affiliation: Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany

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  • Joan Teyra,

    Affiliation: Structural Bioinformatics, BIOTEC TU, Dresden, Germany

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  • Anne-Kristin Heninger,

    Affiliation: Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany

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  • Ina Poser,

    Affiliation: Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany

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  • Fabienne Prieur,

    Affiliation: Hôpital Nord, Saint Etienne, France

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  • Jérémy Truchetto,

    Affiliations: INSERM, Unit 975 Paris, France, Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Paris, France, CNRS, Unité Mixte de Recherche 7225 Paris, France

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  • Christian Confavreux,

    Affiliation: Hôpital Neurologique, Lyon, France

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  • Cécilia Marelli,

    Affiliations: INSERM, Unit 975 Paris, France, Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Paris, France, CNRS, Unité Mixte de Recherche 7225 Paris, France, APHP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris, France

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  • Alexandra Durr,

    Affiliations: INSERM, Unit 975 Paris, France, Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Paris, France, CNRS, Unité Mixte de Recherche 7225 Paris, France, APHP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris, France

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  • Jean Philippe Camdessanche,

    Affiliation: Hôpital Nord, Saint Etienne, France

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  • Alexis Brice,

    Affiliations: INSERM, Unit 975 Paris, France, Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Paris, France, CNRS, Unité Mixte de Recherche 7225 Paris, France, APHP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris, France

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  • Andrej Shevchenko,

    Affiliation: Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany

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  • M. Teresa Pisabarro,

    Affiliation: Structural Bioinformatics, BIOTEC TU, Dresden, Germany

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  • Giovanni Stevanin,

    Affiliations: INSERM, Unit 975 Paris, France, Université Pierre et Marie Curie-Paris6, Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, Paris, France, CNRS, Unité Mixte de Recherche 7225 Paris, France, APHP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris, France

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  • Frank Buchholz mail

    buchholz@mpi-cbg.de

    Affiliation: Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany

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  • Published: June 29, 2010
  • DOI: 10.1371/journal.pbio.1000408

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Podcast

Posted by frankbuchholz on 09 Aug 2010 at 06:37 GMT

a genome-scale endoribonuclease-prepared short interfering RNA (esiRNA) screen for genes involved in DNA double strand break repair.
http://plosbiology.org/article/info:doi/10.1371/journal.pbio.1000408#article1.front1.article-meta1.abstract2.p1

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No competing interests declared.