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Research Article

Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease

  • Daniel W. Neef,

    Affiliation: Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Michelle L. Turski,

    Affiliation: Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Dennis J. Thiele mail

    dennis.thiele@duke.edu

    Affiliation: Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Published: January 19, 2010
  • DOI: 10.1371/journal.pbio.1000291

Reader Comments (1)

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HSF1 regulation in protein expression

Posted by shansen on 01 Feb 2010 at 21:10 GMT

Regulation HSF1 might serve to increase protein expression in heterologous expression systems. In particular, membrane proteins are often difficult to obtain in large quantities.

No competing interests declared.