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Research Article

Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds

  • Howard Y Chang,

    Affiliations: Department of Dermatology, Stanford University School of Medicine, Stanford, California, United States of America, Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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  • Julie B Sneddon,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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  • Ash A Alizadeh,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

    ¤1 Current address: Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California, United States of America

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  • Ruchira Sood,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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  • Rob B West,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Kelli Montgomery,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • Jen-Tsan Chi,

    Affiliation: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America

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  • Matt van de Rijn,

    Affiliation: Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America

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  • David Botstein,

    Affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

    ¤2 Current address: Lewis–Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

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  • Patrick O Brown mail

    To whom correspondence should be addressed. E-mail: pbrown@pmgm2.stanford.edu

    Affiliations: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Published: January 13, 2004
  • DOI: 10.1371/journal.pbio.0020007

Reader Comments (1)

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Dermatofibrosarcoma Protuberans (DFSP) occured on a wounded scar-place

Posted by aleksPlos on 31 Jul 2013 at 00:05 GMT

Dear all,

I found your article provoking and interesting, since I was diagnosed a DFSP on a scarred place where a wound occurred due to a high-pressure contact after many (>15) years.
If you are interested in the details, please contact me on my subscription email, or if you don't have access to it, please tell me yours contact email and I will send you my info there.

best regards

No competing interests declared.