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Revisiting an Old Riddle: What Determines Genetic Diversity Levels within Species?

  • Ellen M. Leffler mail,

    emleffler@uchicago.edu (EML); mfp@uchicago.edu (MP)

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

    X
  • Kevin Bullaughey equal contributor,

    equal contributor Contributed equally to this work with: Kevin Bullaughey, Daniel R. Matute, Wynn K. Meyer, Laure Ségurel, Aarti Venkat

    Affiliation: Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America

    X
  • Daniel R. Matute equal contributor,

    equal contributor Contributed equally to this work with: Kevin Bullaughey, Daniel R. Matute, Wynn K. Meyer, Laure Ségurel, Aarti Venkat

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

    X
  • Wynn K. Meyer equal contributor,

    equal contributor Contributed equally to this work with: Kevin Bullaughey, Daniel R. Matute, Wynn K. Meyer, Laure Ségurel, Aarti Venkat

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

    X
  • Laure Ségurel equal contributor,

    equal contributor Contributed equally to this work with: Kevin Bullaughey, Daniel R. Matute, Wynn K. Meyer, Laure Ségurel, Aarti Venkat

    Affiliations: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, United States of America

    X
  • Aarti Venkat equal contributor,

    equal contributor Contributed equally to this work with: Kevin Bullaughey, Daniel R. Matute, Wynn K. Meyer, Laure Ségurel, Aarti Venkat

    Affiliation: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America

    X
  • Peter Andolfatto,

    Affiliation: Department of Ecology and Evolutionary Biology and the Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

    X
  • Molly Przeworski mail

    emleffler@uchicago.edu (EML); mfp@uchicago.edu (MP)

    Affiliations: Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America, Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, United States of America

    X
  • Published: September 11, 2012
  • DOI: 10.1371/journal.pbio.1001388

Reader Comments (1)

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Epigenetic or organismal complexity maybe the most important factor in determining maximum genetic diversity

Posted by ShiHuang on 14 Sep 2012 at 02:26 GMT

In 2008, we proposed the Maximum Genetic Diversity (MGD) hypothesis to give a more complete account of major evolutionary phenomena. The key difference between MGD and the popular modern evolutionary theory is that one considers genetic diversity today to be mostly at optimum level while the other treats it as still increasing with time indefinitely. The MGD has for the first time solved the mystery of the genetic equidistance result of Margoliash in 1963, which originally mis-inspired the molecular clock and in turn the neutral theory (Huang, 2010, 2012). The neutral theory is however fine for the linear phase of microevolution where genetic diversity/distance is linearly related to time. The MGD has proven useful in solving real world puzzles of the genetic basis of complex traits and diseases (Yuan et al. 2012).

Ref.

Huang, S. (2010) The overlap feature of the genetic equidistance result, a fundamental biological phenomenon overlooked for nearly half of a century. Biological Theory, 5: 40-52.

Huang, S. (2012) Primate phylogeny: molecular evidence for a pongid clade excluding humans and a prosimian clade containing tarsiers. Sci. China Life Sci. 55: 709-725

Yuan, D., Zhu, Z., Tan, X., Liang, J., Zeng, C., Zhang, J., Chen, J., Ma, L., Dogan, A., Brockmann, G., Goldmann, G., Medina, E., Rice, A.D., Moyer, R.W., Man, X., Yi, K., Li, Y., Lu, Q., Huang, Y., Wang, D., Yu, J., Guo, H., Xia, K., and Huang, S. (2012) Minor alleles of common SNPs quantitatively affect traits/diseases and are under both positive and negative selection. arXiv:1209.2911[q-bio.GN]. ( http://arxiv.org/abs/1209...)

No competing interests declared.