Advertisement
Research Article

Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice

  • Andréa M. Caricilli,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

    X
  • Paty K. Picardi,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

    X
  • Lélia L. de Abreu,

    Affiliation: Department of Nursing, State University of Campinas, Campinas, Brazil

    X
  • Mirian Ueno,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

    X
  • Patrícia O. Prada,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

    X
  • Eduardo R. Ropelle,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

    X
  • Sandro Massao Hirabara,

    Affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

    X
  • Ângela Castoldi,

    Affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

    X
  • Pedro Vieira,

    Affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

    X
  • Niels O. S. Camara,

    Affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

    X
  • Rui Curi,

    Affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

    X
  • José B. Carvalheira,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

    X
  • Mário J. A. Saad mail

    msaad@fcm.unicamp.br

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

    X
  • Published: December 06, 2011
  • DOI: 10.1371/journal.pbio.1001212

Reader Comments (4)

Post a new comment on this article

Obesity might be an infectious disease

Posted by Shengxu on 07 Dec 2011 at 19:13 GMT

Many thanks to the authors for the very interesting findings.

I wonder whether wild type mice living together with TLR2-deficient mice for a period of time would develop obesity and insulin resistance. If true, it would imply that some obesity is contagious, which would at least in part explain clustering of obesity in the general population.

No competing interests declared.

RE: Obesity might be an infectious disease

msaad replied to Shengxu on 08 Dec 2011 at 03:57 GMT

The problem with this hypothesis is that you may not have exactly the microbiota of your environment. Certainly characteristics of your immune system will have an important role in the determination of which microbiota you will have.

No competing interests declared.