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Research Article

Protein Thiol Modifications Visualized In Vivo

  • Lars I Leichert,

    Affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Ursula Jakob mail

    To whom correspondence should be addressed. E-mail: ujakob@umich.edu

    Affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

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  • Published: October 05, 2004
  • DOI: 10.1371/journal.pbio.0020333

Reader Comments (1)

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Thiol status of receptors in vivo

Posted by plosbiology on 07 May 2009 at 22:15 GMT

Author: Richard Lanzara
Position: Pharmacologist
Institution: Bio Balance, Inc.
E-mail: biobalance@aol.com
Submitted Date: December 30, 2006
Published Date: January 2, 2007
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Rationale:
I’m trying to generate some cross-disciplinary interest in the fact that many, if not most, G protein-coupled receptors are thiol sensitive proteins.

Our proposal is that in vivo receptors exist as an equilibrium between oxidized (disulfide) and reduced (free thiol) forms (depending on the physiological REDOX milieu), but for many GPCRs, it is the reduced form that functions as the R and R* states.

see:
http://dx.doi.org/10.1016...

Competing interests declared: Principal Scientific Officer, Bio Balance, Inc.