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Research Article

Ancient and Recent Positive Selection Transformed Opioid cis-Regulation in Humans

  • Matthew V Rockman mail,

    To whom correspondence should be addressed. E-mail: mrockman@princeton.edu

    Affiliation: Department of Biology, Duke University, Durham, North Carolina, United States of America

    ¤a Current address: Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

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  • Matthew W Hahn,

    Affiliations: Department of Biology, Duke University, Durham, North Carolina, United States of America, Center for Population Biology, University of California, Davis, California, United States of America

    ¤b Current address: Department of Biology and School of Informatics, Indiana University, Bloomington, Indiana, United States of America

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  • Nicole Soranzo,

    Affiliation: Department of Biology, University College, London, United Kingdom

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  • Fritz Zimprich,

    Affiliation: Department of Clinical Neurology, Medical University of Vienna, Vienna, Austria

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  • David B Goldstein,

    Affiliations: Department of Biology, Duke University, Durham, North Carolina, United States of America, Department of Biology, University College, London, United Kingdom, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Gregory A Wray

    Affiliations: Department of Biology, Duke University, Durham, North Carolina, United States of America, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Published: November 15, 2005
  • DOI: 10.1371/journal.pbio.0030387

Reader Comments (1)

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Population stratification mitigation

Posted by plosbiology on 07 May 2009 at 22:12 GMT

Author: John Carr
Position: Amatuer Genetic Genealogist
E-mail: jcarrgensearch@earthlink.net
Submitted Date: December 20, 2005
Published Date: December 27, 2005
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Your paper was very interesting with significant practical application. I would like to ask if the DNA contributors in these various populations were ranked as to their intellectual position in their societies. Such as, were they all doctors or nurses or individuals prominent in their regional or ethnic group or laborers? You mentioned in the paper that stratification would probably exist within a population as well as between populations. What steps did you take to mitigate that effect on the results of your study?

Thank you,

John Carr

No competing interests declared.