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How to Make Evolution-Proof Insecticides for Malaria Control

  • Andrew F Read mail,

    To whom correspondence should be addressed. E-mail:

  • Penelope A Lynch,
  • Matthew B Thomas
  • Published: April 07, 2009
  • DOI: 10.1371/journal.pbio.1000058

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Lowering insecticide concentrations is dangerous

Posted by plosbiology on 07 May 2009 at 22:29 GMT

Author: Olivier Briet
Position: PhD / Epidemiology, MSc / Entomology
Institution: TRAC Plus-Palu / Rwanda
Submitted Date: April 16, 2009
Published Date: April 17, 2009
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Thank you for your interesting article.
Your suggestion that "existing insecticides could be evolution-proofed by changing concentrations delivered in the field" deserves further exploration. A lower concentration may indeed delay the spread of a single gene mutation that conveys full resistance to the conventional concentration. However, a lower concentration enhances the chances of selection for alleles that convey partial resistance.

No competing interests declared.