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Research Article

Role of CBP and SATB-1 in Aging, Dietary Restriction, and Insulin-Like Signaling

  • Minhua Zhang,

    Affiliation: Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Michal Poplawski,

    Affiliation: Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Kelvin Yen,

    Affiliation: Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Hui Cheng,

    Affiliation: Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Erik Bloss,

    Affiliation: Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Xiao Zhu,

    Affiliation: Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Harshil Patel,

    Affiliation: Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Charles V. Mobbs mail

    charles.mobbs@mssm.edu

    Affiliations: Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York, United States of America

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  • Published: November 17, 2009
  • DOI: 10.1371/journal.pbio.1000245

Reader Comments (1)

Post a new comment on this article

Can we make it more realistic?

Posted by smcboo on 23 Nov 2009 at 15:40 GMT

Reduction of 30% is hard for adhere. However, if it is interleaved by treats, say once a day or once in a few days may be more acceptable to most people. The issue is how much negative effect such treats will last. I would like to see research on effect of such a scheme - eating one meal a day or eating a decent meal every few days. If proved effective, that will be a new lifestyle to promote.

No competing interests declared.