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Research Article

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

  • Della C. David,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Noah Ollikainen,

    Affiliation: Graduate Program in Biological and Medical Informatics, University of California San Francisco, San Francisco, California, United States of America

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  • Jonathan C. Trinidad,

    Affiliation: Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Michael P. Cary,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Alma L. Burlingame,

    Affiliation: Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Cynthia Kenyon mail

    cynthia.kenyon@ucsf.edu

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Published: August 10, 2010
  • DOI: 10.1371/journal.pbio.1000450

Reader Comments (1)

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What's old is new again...

Posted by rejuvenologist on 19 Jan 2011 at 18:35 GMT

The author's assertion of opening "a new field of research into the role of inherent protein aggregation in normal aging and in disease-related aggregation" is surprising given the decades-long appreciation and research of lipofuchsin in aging and disease.

No competing interests declared.