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Research Article

Proboscidean Mitogenomics: Chronology and Mode of Elephant Evolution Using Mastodon as Outgroup

  • Nadin Rohland equal contributor,

    equal contributor Contributed equally to this work with: Nadin Rohland, Anna-Sapfo Malaspinas

    Affiliation: Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany

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  • Anna-Sapfo Malaspinas equal contributor,

    equal contributor Contributed equally to this work with: Nadin Rohland, Anna-Sapfo Malaspinas

    Affiliations: Department of Integrative Biology, University of California Berkeley, Berkeley, California, United States of America, Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland

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  • Joshua L Pollack,

    Affiliation: Department of Integrative Biology, University of California Berkeley, Berkeley, California, United States of America

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  • Montgomery Slatkin,

    Affiliation: Department of Integrative Biology, University of California Berkeley, Berkeley, California, United States of America

    X
  • Paul Matheus,

    Affiliation: Alaska Quaternary Center, University of Alaska Fairbanks, Fairbanks, Alaska, United States of America

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  • Michael Hofreiter mail

    To whom correspondence should be addressed. E-mail: hofreite@eva.mpg.de

    Affiliation: Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany

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  • Published: July 24, 2007
  • DOI: 10.1371/journal.pbio.0050207

Reader Comments (1)

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Mitochondrial Genome of the Mastodon highlights Human Constitutions.

Posted by plosbiology on 07 May 2009 at 22:19 GMT

Author: Sergio Stagnaro
Position: Researcher in Biophysical Semeiotics
Institution: Biophysical Semeiotics Research Laboratory, Riva Trigoso (Genova) Italy
E-mail: dottsergio@semeioticabiofisica.it
Additional Authors: no one
Submitted Date: July 26, 2007
Published Date: August 1, 2007
This comment was originally posted as a “Reader Response” on the publication date indicated above. All Reader Responses are now available as comments.

Editors,
I consider this article really fascinating and interesting as regards particularly the human most common and serious disorders. In fact, determining the complete mitochondrial genome of the mastodon (Mammut americanum), a recently extinct relative of the living elephants that diverged about 26 million years ago, the authors obtained the sequence from a tooth dated to 50,000–130,000 years ago, increasing the specimen age for which such palaeogenomic analyses have been done by almost a complete glacial cycle. Using this sequence, together with mitochondrial genome sequences from two African elephants, two Asian elephants, and two woolly mammoths the same scientists have clearly shown that mammoths are more closely related to Asian than to African elephants, underlining, although unintentionally, the fact that mitochondrial equipment lay a central role in individual constitutions, as I demonstrated in former papers in my 51-year-long clinical research, posted also in PLOS (1-7). In a few words, all biophysical-semeiotic constitutions, in both man and animal, are dependent of an inherited mitochondrial cytopathy, I termed Congenital Acidosic Enzyme-Metabolic Histangiopathy (CAEM), Single Patient Based Medicine is based on (3, 6, 7).

1) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004. http://www.travelfactory....
2) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ed. Travel Factory, Roma, 2004.
3) Stagnaro S., Stagnaro-Neri M. Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Ed. Travel Factory, Roma, 2005.
4) Stagnaro S., Istangiopatia Congenita Acidosica Enzimo-Metabolica. Gazz Med. It. – Asch. Sci, Med. 144, 423, 1985
5) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [Medline]
6) Stagnaro Sergio. Single Patient Based Medicine: its paramount role in Future Medicine. Public Library of Science. 2005. http://medicine.plosjourn...
7) Stagnaro S. Pivotal role of Biophysical Semeiotic Constitutions in Primary Prevention. Cardiovascular Diabetology, 2:1, http://www.cardiab.com/co...

No competing interests declared.